However, to use these novel options in the best possible way, knowledge is required not only of the data from the large clinical trials but also of the biological mechanisms, molecular pathways, immunological mechanisms, and methodological issues related to both new response criteria and endpoints. However, the role of tyrosine kinase inhibitors (TKIs) remains of fundamental importance, especially in patients who, for clinical characteristics, tumor burden and comorbidity, could have greater benefit from the use of TKIs in monotherapy rather than in combination with other therapies. The most recent clinical trials with an ICI-based combination of molecular targeted agents and ICI show how, by restoring an efficient immune response against cancer cells and by establishing an immunological memory, it is possible to obtain not only a better radiological response but also a longer progression-free and overall survival. Fulbright Research Scholar in Singapore, model with Basic Model Management (Singapore), Artist in Residence at Vagabond Hotel with Un-canned Art.Ģ017 (Los Angeles) Creative Resident at 72andSunny.Ģ016 (San Francisco) Facebook Stories intern.Ģ015 (Los Angeles) Model, TEDx Speaker for BIG TALK.Ģ014 (Chicago) Broadcast Journalism student at Northwestern University. Founder and president of MIXED.The therapeutic sc"enario of metastatic renal cell cancer (mRCC) has noticeably increased, ranging from the most studied molecular target therapies to those most recently introduced, up to immune checkpoint inhibitors (ICIs). Speaker at IIE and Microsoft Chicago.Ģ017/2018 (Singapore) U.S. Fulbright Alumni Ambassador presenting on Capitol Hill. ![]() Model for Minelli Management.Ģ020 (US/Australia) BIG TALK public speaking engagements (WeWork, Elite SEM, Adobe, and Google).Ģ019 (US/Kazakhstan) BIG TALK growth and educational program development, and documentary filmmaking for the “New Silk Road’s” entrepreneur showcase project with Narxoz Business School. Model for Minelli Management.Ģ021 (US) BIG TALK media, app, and corporate program development. Developing a documentary about modern-day loneliness and social isolation. Model for Minelli Management.Ģ022 (US) BIG TALK community and corporate/organization events and program development. Developing a documentary about loneliness and connection. Kalina is passionate about projects that help bridge cultures and communities through education, music / the arts, and storytelling. For fun, she stays active (surfing, hiking, tennis, and dancing), adventurous, and creative (painting, songwriting, and playing the piano and guitar).Ģ023 (US) BIG TALK educational program development and video content creator. ![]() Department of State and Institute of International Education studying "How to establish cross-cultural empathy through Big Talk." With a degree in Broadcast Journalism from Northwestern University's Medill School, she has worked on documentary films in Ecuador and Germany on education and the Holocaust. In 2012, Kalina founded MIXED, Northwestern’s first ever Mixed Race Student Coalition. Kalina has lived in Singapore as a Fulbright Research Scholar sponsored by the U.S. Originally from Santa Monica, California, Kalina travels often to present and deliver workshops about Big Talk (her TEDx talk has over 6,500,000 YouTube views) or for video, research, and public relations projects. ![]() Fulbright Ambassador, public presenter and facilitator, community events organizer, artist, and model. Kalina Silverman is an entrepreneur (founder of the award-winning viral media project Big Talk), documentary journalist, US.
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